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Article

Quantifying the utility of type 2 diabetes polygenic risk score for predicting incident diabetes: an analysis of large US-based cohort studies.

BMC medical genomics - 12 May 2026

Hanson Robert L, Kobes Sayuko, Wedekind Lauren E, Arreola Elsa Vazquez, Ramirez-Luzuriaga Maria Jose, Hsueh Wen-Chi

Abstract excerpt

BACKGROUND: Genome-wide association analyses (GWASs) have identified numerous genetic variants associated with type 2 diabetes, but the utility of polygenic risk scores (PRSs) derived from these associations for predicting future incident diabetes remains uncertain. We analyzed utility of PRSs to predict incident diabetes in longitudinal studies, consisting of African Americans (AfrAm) and European Americans...

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Identifiers

PMID: 42120982
DOI: 10.1186/s12920-026-02386-7
PMCID: PMC13343701

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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