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Polygenic risk score refines cardiovascular disease risk in individuals with type 2 diabetes at borderline or intermediate risk.

Journal of diabetes investigation - 1 Jun 2026

Choi Jaewon, Lee Hyunsuk, Rhee Tae-Min, Park Jun-Bean, Kwak Soo Heon

Abstract excerpt

To evaluate whether a coronary artery disease (CAD) polygenic risk score (PRS) can improve atherosclerotic cardiovascular disease (ASCVD) risk stratification in individuals with type 2 diabetes (T2D), particularly those at borderline or intermediate 10-year risk. In the UK Biobank (n = 340,299), we integrated CAD PRS into the Pooled Cohort Equations (PCE) to evaluate whether it improved the prediction of incident...

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Cardiovascular Diseases
Coronary Artery Disease
Diabetes Mellitus, Type 2
Genetic Risk Score
Heart Disease Risk Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Risk Assessment

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PMID: 41928601
DOI: 10.1111/jdi.70304

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CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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