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Incorporating polygenic risk into the Leicester Risk Assessment score for 10-year risk prediction of type 2 diabetes.

Diabetes & metabolic syndrome - 1 Apr 2024

Liu Xiaonan, Littlejohns Thomas J, Bešević Jelena, Bragg Fiona, Clifton Lei, Collister Jennifer A, Trichia Eirini, Gray Laura J, Khunti Kamlesh, Hunter David J

Abstract excerpt

AIMS: We evaluated whether incorporating information on ethnic background and polygenic risk enhanced the Leicester Risk Assessment (LRA) score for predicting 10-year risk of type 2 diabetes. METHODS: The sample included 202,529 UK Biobank participants aged 40-69 years. We computed the LRA score, and developed two new risk scores using training data (80% sample): LRArev, which incorporated additional information...

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PMID: 38608567
DOI: 10.1016/j.dsx.2024.102996

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