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Genomic risk prediction for type 2 diabetes in Australian individuals aged 70 years and older.

Diabetes, obesity & metabolism - 1 Sept 2025

Yu Chenglong, Zhou Zhen, Neumann Johannes T, Lin Tian, Robb Catherine, Fransquet Peter, McNeil John J, Wray Naomi R, Zoungas Sophia, Lacaze Paul

Abstract excerpt

AIMS: The utility of a polygenic score (PGS) for type 2 diabetes (T2D) has been demonstrated in the general adult population. However, while previous studies have included older adults within broader age ranges, the performance of PGS specifically in older individuals aged ≥70 years remains unclear. We aimed to evaluate the predictive utility of a PGS in an older cohort. MATERIALS AND METHODS: We derived a PGS in...

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PMID: 40600463
DOI: 10.1111/dom.16579
PMCID: PMC12340776

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