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Comparison of polygenic risk scores for type 2 diabetes developed from different ancestry groups

3 May 2025

Abstract excerpt

Polygenic risk scores (PRS) are useful for assessing disease risk; however, knowledge about their effectiveness among Asian and other populations is limited. This study aimed to compare the classification accuracy of PRSs for type 2 diabetes (T2D-PRS) developed from different ancestry groups using genotype data from 14,083 Japanese participants. Participants' scores were calculated using T2D-PRS models, and...

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PMID: 40603767
DOI: 10.1038/s44324-025-00059-0

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