Genes, other than Muc5b, are associated with bleomycin-induced lung injury.

doi:10.1038/s42003-026-10239-3

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Article

Genes, other than Muc5b, are associated with bleomycin-induced lung injury.

Communications biology - 12 May 2026

Wang Yingping, Hennessy Corinne, Dobrinskikh Evgenia, Humphries Stephen M, Hatakka Kristina, Ackert-Bicknell Cheryl L, Godfrey Dana A, Kelada Samir N P, Keele Gregory R, Cardwell Jonathan, Peljto Anna, Clouthier David E, Yang Ivana V, Schwartz David A

Abstract excerpt

The MUC5B promoter variant rs35705950 is the dominant risk factor for the development of idiopathic pulmonary fibrosis (IPF), yet its low penetrance remains unexplained. All eight founder strains of the Diversity Outbred (DO) mouse population carry the risk allele at the orthologous site, yet exhibited variable bleomycin-induced MUC5B expression and fibrosis severity. Herein, using the DO bleomycin model, we find...

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Identifiers

PMID: 42120750
DOI: 10.1038/s42003-026-10239-3
PMCID: PMC13392033

Genes

MUC5B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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