Article
Regulation of MUC5B Expression in Idiopathic Pulmonary Fibrosis.
American journal of respiratory cell and molecular biology - 1 Jul 2017
Helling Britney A, Gerber Anthony N, Kadiyala Vineela, Sasse Sarah K, Pedersen Brent S, Sparks Lenore, Nakano Yasushi, Okamoto Tsukasa, Evans Christopher M, Yang Ivana V, Schwartz David A
Abstract excerpt
The gain-of-function mucin 5B (MUC5B) promoter variant, rs35705950, confers the largest risk, genetic or otherwise, for the development of idiopathic pulmonary fibrosis; however, the mechanisms underlying the regulation of MUC5B expression have yet to be elucidated. Here, we identify a critical regulatory domain that contains the MUC5B promoter variant and has a highly conserved forkhead box protein A2 (FOXA2)...
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