Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A regulatory network underlying idiopathic pulmonary fibrosis.

Frontiers in immunology - 1 Jan 2026

Li Ganggang, Pan Xiaochuan, Wang Yuanyuan, Lan Peishu, Li Jie, Wu Xuanyu, He Yanyun, Wen Hongdan, Cheng Zhitian, Du Quanyu, Wu Wenbin

Abstract excerpt

Background: Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease in which genetic susceptibility interacts with epithelial, immune, and mesenchymal remodeling. Although the chromosome 11p15.5 locus contains established IPF susceptibility signals near MUC5B and TOLLIP, the broader regulatory architecture of this region remains incompletely resolved. Methods: We integrated IPF genome-wide...

Read the complete abstract on PubMed

Topics

Idiopathic Pulmonary Fibrosis
Animals
Humans
Gene Regulatory Networks
Rats
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Quantitative Trait Loci

Genetic Predisposition to Disease

Mucin-5B

Disease Models, Animal

Intracellular Signaling Peptides and Proteins

Bleomycin

DNA Methylation

Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 42694191
DOI: 10.3389/fimmu.2026.1919175
PMCID: PMC13537991

Genes

BRSK2
CDC25B
FOXA2
MUC5B
TOLLIP
NFE2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A regulatory network underlying idiopathic pulmonary fibrosis.PMID 42694191Read ↗

Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosisSemantic proximity Read ↗

IDIOPATHIC PULMONARY FIBROSIS IS A COMPLEX GENETIC DISORDER.Semantic proximity Read ↗

Genome-wide association study of susceptibility to idiopathic pulmonary fibrosisSemantic proximity Read ↗

Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study.Semantic proximity Read ↗

Transcriptomics in idiopathic pulmonary fibrosis unveiled: a new perspective from differentially expressed genes to therapeutic targetsSemantic proximity Read ↗

Integrated RNA sequencing reanalysis reveals reproducible matrix-immune signatures in idiopathic pulmonary fibrosisSemantic proximity Read ↗

Integrative Analyses Reveal Novel Disease-associated Loci and Genes for Idiopathic Pulmonary FibrosisSemantic proximity Read ↗

Exploring the Cellular and Molecular Landscape of Idiopathic Pulmonary Fibrosis: Integrative Multi-Omics and Single-Cell AnalysisSemantic proximity Read ↗

Single cell transcriptomics in a treatment-segregated cohort exposes a STAT3-regulated therapeutic gap in idiopathic pulmonary fibrosisSemantic proximity Read ↗

Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.Semantic proximity Read ↗

Elucidating the causal associations and mechanisms between circulating immune cells and idiopathic pulmonary fibrosis: new insights from Mendelian randomization and transcriptomics.Semantic proximity Read ↗

Integrative analysis of lung molecular signatures reveals key drivers of idiopathic pulmonary fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.