Article
A Polygenic Risk Score for Idiopathic Pulmonary Fibrosis and Interstitial Lung Abnormalities.
American journal of respiratory and critical care medicine - 1 Oct 2023
Moll Matthew, Peljto Anna L, Kim John S, Xu Hanfei, Debban Catherine L, Chen Xianfeng, Menon Aravind, Putman Rachel K, Ghosh Auyon J, Saferali Aabida, Nishino Mizuki, Hatabu Hiroto, Hobbs Brian D, Hecker Julian, McDermott Gregory, Sparks Jeffrey A, Wain Louise V, Allen Richard J, Tobin Martin D, Raby Benjamin A, Chun Sung, Silverman Edwin K, Zamora Ana C, Ortega Victor E, Garcia Christine K, Barr R Graham, Bleecker Eugene R, Meyers Deborah A, Kaner Robert J, Rich Stephen S, Manichaikul Ani, Rotter Jerome I, Dupuis Josée, O'Connor George T, Fingerlin Tasha E, Hunninghake Gary M, Schwartz David A, Cho Michael H
Abstract excerpt
Rationale: In addition to rare genetic variants and the MUC5B locus, common genetic variants contribute to idiopathic pulmonary fibrosis (IPF) risk. The predictive power of common variants outside the MUC5B locus for IPF and interstitial lung abnormalities (ILAs) is unknown. Objectives: We tested the predictive value of IPF polygenic risk scores (PRSs) with and without the MUC5B region on IPF, ILA, and ILA...
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