Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Modulating hepatic stellate cell senescence: A promising therapeutic strategy for liver fibrosis.

Hepatobiliary & pancreatic diseases international : HBPD INT - 1 Aug 2026

Sharmila Muthusethupathi, Shree Harini Karthik, Ezhilarasan Devaraj

Abstract excerpt

Fibrosis is characterized by the abnormal deposition of extracellular matrix (ECM) components in liver tissue following chronic liver injury, ultimately leading to hepatic cirrhosis. Following liver damage, hepatic stellate cells (HSCs) undergo transition from a quiescent to an activated phenotype which differentiate into proliferative, fibrogenic, and contractile myofibroblasts. The activated HSCs act as the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cellular Senescence

Share to Hepatic Stellate Cells

Share to Liver Cirrhosis

Share to Phenotype

Share to Signal Transduction

Source

Identifiers

PMID: 42120279
DOI: 10.1016/j.hbpd.2026.04.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modulating hepatic stellate cell senescence: A promising therapeutic strategy for liver fibrosis.PMID 42120279Read ↗

Role of cellular senescence in hepatic diseases (Review)Semantic proximity Read ↗

Navigating the complex role of senescence in liver diseaseSemantic proximity Read ↗

Cellular senescence in liver fibrosis: Implications for age-related chronic liver diseasesSemantic proximity Read ↗

Cellular senescence in the cholangiopathiesSemantic proximity Read ↗

Biliary Epithelial Senescence in Liver Disease: There Will Be SASPSemantic proximity Read ↗

Molecular interplays in hepatic stellate cells: apoptosis, senescence, and phenotype reversion as cellular connections that modulate liver fibrosis.Semantic proximity Read ↗

Aging and Aging-Related Senescence in LiverSemantic proximity Read ↗

Hepatic senescence, the good and the badSemantic proximity Read ↗

Cellular senescence and its pathogenic and therapeutic implications in autoimmune hepatitis.Semantic proximity Read ↗

Identification of STAT3 as a biomarker for cellular senescence in liver fibrosis: A bioinformatics and experimental validation studySemantic proximity Read ↗

Phenotypes and ontogeny of senescent hepatic stellate cells in metabolic dysfunction-associated steatohepatitis.Semantic proximity Read ↗

Functional Role of Cellular Senescence in Biliary InjurySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.