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Functional Role of Cellular Senescence in Biliary Injury

22 Jan 2015

Abstract excerpt

Cellular senescence is a state of irreversible cell cycle arrest that has been involved in many gastrointestinal diseases, including human cholestatic liver disorders. Senescence may play a role in biliary atresia, primary sclerosing cholangitis, cellular rejection, and primary biliary cirrhosis, four liver diseases affecting cholangiocytes and the biliary system. In this review, we examine proposed mechanisms of...

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PMID: 25619959
DOI: 10.1016/j.ajpath.2014.10.027

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