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Cellular senescence and its pathogenic and therapeutic implications in autoimmune hepatitis.

Expert review of gastroenterology & hepatology - 1 Nov 2024

Czaja Albert J

Abstract excerpt

INTRODUCTION: Senescent cells are characterized by replicative arrest and phenotypes that produce diverse pro-inflammatory and pro-oxidant mediators. The senescence of diverse hepatic cell types could constitute an unrecognized pathogenic mechanism and prognostic determinant in autoimmune hepatitis. The impact of cellular senescence in autoimmune hepatitis is unknown, and it may suggest adjunctive management...

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Identifiers

PMID: 39575891
DOI: 10.1080/17474124.2024.2432480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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