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Navigating the complex role of senescence in liver disease

16 Dec 2024

Abstract excerpt

ABSTRACT: Cellular senescence, an irreversible state of cell cycle arrest characterized by phenotypic changes and a specific secretory profile, plays a dual role in liver health and disease. Under physiological conditions, senescence aids organ repair and regeneration, but its accumulation due to aging or pathological stress significantly contributes to chronic liver diseases, including alcoholic liver disease,...

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PMID: 39679454
DOI: 10.1097/cm9.0000000000003439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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