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Article

Evolution and transmission of drug-resistant tuberculosis in a Russian population.

Nature genetics - 1 Mar 2014

Casali Nicola, Nikolayevskyy Vladyslav, Balabanova Yanina, Harris Simon R, Ignatyeva Olga, Kontsevaya Irina, Corander Jukka, Bryant Josephine, Parkhill Julian, Nejentsev Sergey, Horstmann Rolf D, Brown Timothy, Drobniewski Francis

Abstract excerpt

The molecular mechanisms determining the transmissibility and prevalence of drug-resistant tuberculosis in a population were investigated through whole-genome sequencing of 1,000 prospectively obtained patient isolates from Russia. Two-thirds belonged to the Beijing lineage, which was dominated by two homogeneous clades. Multidrug-resistant (MDR) genotypes were found in 48% of isolates overall and in 87% of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24464101
DOI: 10.1038/ng.2878
PMCID: PMC3939361

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