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Article

Identification of Novel Proteins Mediating Causal Association Between Smoking and Essential Hypertension: A Mendelian Randomization Study.

Journal of the American Heart Association - 3 Dec 2024

Shi Jikang, Liang Zhuoshuai, Liu Zhantong, Pan Lingfeng, Hu Xinmeng, Tian Yuyang, Jin Huizhen, Liu Yawen, Cheng Yi, Zhang Ming

Abstract excerpt

BACKGROUND: Smoking is a factor for hypertension. We aim to reveal novel plasma proteins mediating the relationship of smoking with hypertension and identify potential drug targets for hypertension on the basis of Mendelian randomization design. METHODS AND RESULTS: Data for smoking were selected from the largest genome-wide association study meta-analysis performed by the Genome-Wide Association Study and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 39604029
DOI: 10.1161/JAHA.124.036202
PMCID: PMC11681583

Genes

IFNLR1
PLAT
ANXA4
KLB
MMP8
DLK1
POSTN
SAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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