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Sodium-glucose cotransporter protein 2 inhibition, plasma proteins, and ischemic stroke: A mediation Mendelian randomization and colocalization study.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association - 1 Jan 2025

Chen Zhiqing, Meng Hongmei, Guo Yujin, Sun Huaiyu, Zhang Wuqiong, Guo Yu, Hou Shuai

Abstract excerpt

PURPOSE: To determine the effect of the sodium-glucose cotransporter protein 2 (SGLT2) inhibition on ischemic stroke (IS) and investigate the circulating proteins that mediate the effects of SGLT2 inhibition on IS. METHODS: The effects of SGLT2 inhibition on IS were evaluated using two-sample Mendelian randomization (MR) analyses. The 4,907 circulating proteins from the plasma proteome were assessed to identify...

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PMID: 39542148
DOI: 10.1016/j.jstrokecerebrovasdis.2024.108136

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