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Article

Systematic Druggable Genome-Wide Mendelian Randomization Identifies Therapeutic Targets for Functional Outcome After Ischemic Stroke.

Journal of the American Heart Association - 20 Aug 2024

Zhang Lu-Yang, Chu Yun-Hui, You Yun-Fan, Dong Ming-Hao, Pang Xiao-Wei, Chen Lian, Zhu Li-Fang, Yang Sheng, Zhou Luo-Qi, Shang Ke, Deng Gang, Xiao Jun, Wang Wei, Qin Chuan, Tian Dai-Shi

Abstract excerpt

BACKGROUND: Stroke is a leading cause of death worldwide, with a lack of effective treatments for improving the prognosis. The aim of the present study was to identify novel therapeutic targets for functional outcome after ischemic stroke . METHODS AND RESULTS: Cis-expression quantitative trait loci data for druggable genes were used as instrumental variables. The primary outcome was the modified Rankin Scale...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39119979
DOI: 10.1161/JAHA.124.034749
PMCID: PMC11963950

Genes

ABCC2
NRBP1
PI3
SEMG1
ATRAID
BLK
CD93
CHST13
NR1H3
RIPK4
SLC22A4
SLC22A5
SLCO3A1
TEK
TLR4
WNT10B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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