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Article

Effect of Individual and Combined Cytochrome P450 Activity Scores on Symptom Improvement and Side Effects in Youth Treated With Sertraline.

Clinical and translational science - 1 May 2026

Gerlach Samuel, Maruf Abdullah Al, Shaheen Sarker M, McCloud Ryden, Heintz Madison, McAusland Laina, Arnold Paul D, Bousman Chad A

Abstract excerpt

Sertraline is commonly used to treat mental health conditions in youth. However, its tolerability and efficacy vary between individuals, partly due to interindividual differences in drug metabolism. This study assessed the individual and combined impact of genetic variation in cytochrome P450 drug-metabolizing enzymes on patient-reported side effects and symptom improvement in 347 youth, aged 6-24, receiving...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42115785
DOI: 10.1111/cts.70590
PMCID: PMC13160929

Genes

CYP3A4
CYP2B6
CYP2C19
CYP2C9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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