Exploring the role of drug-metabolising enzymes in antidepressant side effects.

doi:10.1007/s00213-015-3898-x

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Article

Exploring the role of drug-metabolising enzymes in antidepressant side effects.

Psychopharmacology - 1 Jul 2015

Hodgson Karen, Tansey Katherine E, Uher Rudolf, Dernovšek Mojca Zvezdana, Mors Ole, Hauser Joanna, Souery Daniel, Maier Wolfgang, Henigsberg Neven, Rietschel Marcella, Placentino Anna, Craig Ian W, Aitchison Katherine J, Farmer Anne E, Dobson Richard J B, McGuffin Peter

Abstract excerpt

RATIONALE: Cytochrome P450 enzymes are important in the metabolism of antidepressants. The highly polymorphic nature of these enzymes has been linked to variability in antidepressant metabolism rates, leading to hope regarding the use of P450 genotyping to guide treatment. However, evidence that P450 genotypic differences underlie the variation in treatment outcomes is inconclusive. OBJECTIVES: We explored the...

Topics

Adult
Antidepressive Agents
Antidepressive Agents, Second-Generation
Antidepressive Agents, Tricyclic
Citalopram
Cohort Studies
Cytochrome P-450 CYP2C19
Cytochrome P-450 CYP2D6
Cytochrome P-450 Enzyme System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Depression

Female

Genotype

Humans

Male

Nortriptyline

Treatment Outcome

Source

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Identifiers

PMID: 25761838
DOI: 10.1007/s00213-015-3898-x
PMCID: PMC4480333

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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