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Article

Associations of CYP2B6, CYP2C19, and CYP2D6 isoforms and phenoconversion with sertraline pharmacokinetics.

PloS one - 1 Jan 2026

Tapia-Alzuguren Begoña, Canga-Espina Covadonga, Molero Patricio, Aldaz Azucena

Abstract excerpt

Interindividual variability in sertraline exposure is substantial and may be influenced by genetic variation in drug-metabolizing enzymes as well as by concomitant medications that modify enzyme activity. This study explored the association between genetic variability in the cytochrome P450 isoforms CYP2B6, CYP2C19, and CYP2D6 and sertraline pharmacokinetics in a real-world clinical setting, accounting for...

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Share to Cytochrome P-450 CYP2B6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42268801
DOI: 10.1371/journal.pone.0351241
PMCID: PMC13252811

Genes

CYP2B6
CYP2C19

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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