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Article

Sertraline dosing trends in children and adolescents stratified by CYP2C19 genotype.

Pharmacogenomics - 1 Mar 2022

Brown Jacob T, Gregornik David B, Jorgenson Alissa, Watson Dave, Roiko Samuel A, Bishop Jeffrey R

Abstract excerpt

Aim: Sertraline is a CYP2C19 substrate commonly prescribed to children with anxiety. Materials & methods: This medical record review examined dosing trends and treatment discontinuation in children prescribed sertraline with documented CYP2C19 genotypes. Variables collected included age, weight, diagnosis, concomitant medications, initial sertraline dose, dose changes and CYP2C19 genotypes. Results: A total of 90...

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Identifiers

PMID: 35083916
DOI: 10.2217/pgs-2021-0135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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