Article
Effect of Cytochrome P450 polymorphism on the action and metabolism of selective serotonin reuptake inhibitors.
Expert opinion on drug metabolism & toxicology - 1 Jan 2015
Probst-Schendzielorz Kristina, Viviani Roberto, Stingl Julia C
Abstract excerpt
INTRODUCTION: The aim of this article is to review the field of clinically relevant pharmacogenetic effects of cytochrome P450 polymorphisms on metabolism, kinetics, and action of selective serotonin reuptake inhibitors (SSRIs). AREAS COVERED: The relevant literature in humans on the implications of genetic variation on SSRI drug exposure, drug safety, and efficacy was systematically evaluated. There is a large...
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