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Article

Impact of CYP2C19 genotype on sertraline exposure in 1200 Scandinavian patients.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Feb 2020

Bråten Line S, Haslemo Tore, Jukic Marin M, Ingelman-Sundberg Magnus, Molden Espen, Kringen Marianne K

Abstract excerpt

Sertraline is an (SSRI-)antidepressant metabolized by the polymorphic CYP2C19 enzyme. The aim of this study was to investigate the impact of CYP2C19 genotype on the serum concentrations of sertraline in a large patient population. Second, the proportions of patients in the various CYP2C19 genotype-defined subgroups obtaining serum concentrations outside the therapeutic range of sertraline were assessed. A total...

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Identifiers

PMID: 31649299
DOI: 10.1038/s41386-019-0554-x
PMCID: PMC6969041

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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