Article
Pharmacogenetics to Predict Adverse Events Associated With Antidepressants.
Pediatrics - 1 Dec 2020
Rossow Katelyn M, Aka Ida T, Maxwell-Horn Angela C, Roden Dan M, Van Driest Sara L
Abstract excerpt
OBJECTIVES: To determine the association between cytochrome P450 2C19 (CYP2C19) metabolizer status and risk for escitalopram and citalopram, collectively termed (es)citalopram, and sertraline adverse events (AEs) in children. METHODS: In this retrospective cohort study, we used deidentified electronic health records linked to DNA. The cohort included children ≤18 years with ≥2 days of (es)citalopram or ≥7 days of...
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