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Article

Effect of Polymorphisms on the Pharmacokinetics, Pharmacodynamics and Safety of Sertraline in Healthy Volunteers.

Basic & clinical pharmacology & toxicology - 1 May 2018

Saiz-Rodríguez Miriam, Belmonte Carmen, Román Manuel, Ochoa Dolores, Koller Dora, Talegón María, Ovejero-Benito María C, López-Rodríguez Rosario, Cabaleiro Teresa, Abad-Santos Francisco

Abstract excerpt

Sertraline is a selective serotonin reuptake inhibitor widely metabolized in the liver by cytochrome P450 (CYP) enzymes. Besides, it is a P-glycoprotein substrate. Moreover, serotonin transporters and serotonin receptors are involved in its efficacy and safety. The aim of this study was to evaluate the role of polymorphisms of metabolizing enzymes, transporters and receptors on the pharmacokinetics,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2B6

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Identifiers

PMID: 29136336
DOI: 10.1111/bcpt.12938

Genes

ABCB1

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