Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of PTPRR gene associated with cirrhosis and sarcopenia based on bioinformatics and machine learning.

European journal of clinical nutrition - 1 Aug 2026

Ran Shu, Li Haopeng, Li Zhichen, Li Yuehua, Fang Yapeng, Liu Baolin

Abstract excerpt

BACKGROUND: Cirrhosis and sarcopenia frequently coexist and are associated with poor clinical outcomes; however, their shared genetic basis remains incompletely understood. METHODS: We applied conditional and conjunctional false discovery rate (cFDR/ccFDR) analyses to genome-wide association study (GWAS) summary statistics for cirrhosis and sarcopenia-related traits, including appendicular lean mass (ALM) and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Fibrosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome-Wide Association Study

Share to Liver Cirrhosis

Share to Machine Learning

Share to Muscle, Skeletal

Share to Sarcopenia

Share to Transcriptome

Source

Identifiers

PMID: 42115738
DOI: 10.1038/s41430-026-01752-z

Genes

PTPRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of PTPRR gene associated with cirrhosis and sarcopenia based on bioinformatics and machine learning.PMID 42115738Read ↗

Multi-omics and molecular testing: A new insight into the genetic mechanisms of primary biliary cholestasis and sarcopeniaSemantic proximity Read ↗

Effects of nonalcoholic fatty liver disease on sarcopenia: evidence from genetic methodsSemantic proximity Read ↗

Multi-trait Genome-Wide Analysis Identified 20 Novel Loci for Sarcopenia-Related Traits in UK Biobank.Semantic proximity Read ↗

Identifying Susceptibility Genes and Shared Genetic Architecture for Longevity and Muscle Weakness.Semantic proximity Read ↗

Genetic variants that associate with cirrhosis have pleiotropic effects on human traits.Semantic proximity Read ↗

Shared genetic architecture of type 2 diabetes with muscle mass and function and frailty reveals comorbidity etiology and pleiotropic druggable targets.Semantic proximity Read ↗

Sarcopenia and chronic pain: Identification of shared genetic determinants and therapeutic implication.Semantic proximity Read ↗

Exploration of the core gene signatures and mechanisms between NAFLD and sarcopenia through transcriptomic levelSemantic proximity Read ↗

Mapping the genetically predicted associations of plasma metabolites with sarcopenia and aging traits: Evidence from bidirectional Mendelian randomization and transcriptome analysis.Semantic proximity Read ↗

Association Analysis of the Circulating Proteome With Sarcopenia‐Related Traits Reveals Potential Drug Targets for SarcopeniaSemantic proximity Read ↗

Putative Candidate Drug Targets for Sarcopenia-Related Traits Identified Through Mendelian Randomization Analysis of the Blood ProteomeSemantic proximity Read ↗

Primary biliary cirrhosis and rheumatoid arthritis: a comprehensive study combining genetics and transcriptomics.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.