Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sarcopenia and chronic pain: Identification of shared genetic determinants and therapeutic implication.

Medicine - 15 May 2026

Li Juan, Huang Jiaqi, Han Jiang

Abstract excerpt

Sarcopenia and chronic pain are prevalent age-related conditions with substantial health impacts, yet their causal relationship remains unclear. Our aim is to study the bidirectional causal relationship among these diseases and identify potential therapeutic targets through genetic methods, as well as explore new therapeutic drugs. We performed bidirectional Mendelian randomization and Bayesian colocalization...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to Chronic Pain
Share to ABCC8 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MYBPC3 gene

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Polymorphism, Single Nucleotide

Share to Sarcopenia

Source

Open in PubMed Open full text

Identifiers

PMID: 42152289
DOI: 10.1097/MD.0000000000048819
PMCID: PMC13183096

Genes

ABCC8
DDAH1
MAPKAPK3
SUOX
FAM177B
MYBPC3
POLR2L
RFTN2
RMDN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Sarcopenia and chronic pain: Identification of shared genetic determinants and therapeutic implication.PMID 42152289Read ↗

Multi-omics and molecular testing: A new insight into the genetic mechanisms of sarcopenia and arthritis.Semantic proximity Read ↗

Multi-omics and molecular testing: A new insight into the genetic mechanisms of sarcopenia and arthritisSemantic proximity Read ↗

Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for sarcopenia.Semantic proximity Read ↗

Identifying genetic determinants of sarcopenia-related traits: a Mendelian randomization study of druggable genes.Semantic proximity Read ↗

Dissecting Immune Mechanisms Underlying Sarcopenia Using Multi-omics Approaches.Semantic proximity Read ↗

Sarcopenia and immune-mediated inflammatory diseases: Evaluating causality and exploring therapeutic targets for sarcopenia through Mendelian randomization.Semantic proximity Read ↗

Pleiotropic effects on Sarcopenia subphenotypes point to potential molecular markers for the disease.Semantic proximity Read ↗

Association between polygenetic risk scores related to sarcopenia risk and their interactions with regular exercise in a large cohort of Korean adults.Semantic proximity Read ↗

Association Analysis of the Circulating Proteome With Sarcopenia‐Related Traits Reveals Potential Drug Targets for SarcopeniaSemantic proximity Read ↗

Shared Genetic Regulatory Networks Contribute to Neuropathic and Inflammatory Pain: Multi-Omics Systems AnalysisSemantic proximity Read ↗

Identification of novel biomarkers and drug targets for frailty-related skeletal muscle aging: a multi-omics studySemantic proximity Read ↗

Mapping the genetically predicted associations of plasma metabolites with sarcopenia and aging traits: Evidence from bidirectional Mendelian randomization and transcriptome analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.