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Article

TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.

Molecular cell - 19 Mar 2015

Blackford Andrew N, Nieminuszczy Jadwiga, Schwab Rebekka A, Galanty Yaron, Jackson Stephen P, Niedzwiedz Wojciech

Abstract excerpt

The Bloom syndrome helicase BLM and topoisomerase-IIβ-binding protein 1 (TopBP1) are key regulators of genome stability. It was recently proposed that BLM phosphorylation on Ser338 mediates its interaction with TopBP1, to protect BLM from ubiquitylation and degradation (Wang et al., 2013). Here,...

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Source

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Identifiers

PMID: 25794620
DOI: 10.1016/j.molcel.2015.02.012
PMCID: PMC4374139

Genes

BLM
MDC1
RMI1
RMI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25794620-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.PMID 25794620Read ↗

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The DNA helicase activity of BLM is necessary for the correction of the genomic instability of bloom syndrome cells.Semantic proximity Read ↗

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More complexity to the Bloom's syndrome complex.Semantic proximity Read ↗

Mechanism of Bloom syndrome complex assembly required for double Holliday junction dissolution and genome stability.Semantic proximity Read ↗

Bloom helicase and DNA topoisomerase IIIalpha are involved in the dissolution of sister chromatids.Semantic proximity Read ↗

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Evidence for BLM and Topoisomerase IIIalpha interaction in genomic stability.Semantic proximity Read ↗

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