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Article

Association of parental dementia with cognitive and brain MRI measures in middle-aged adults.

Neurology - 15 Dec 2009

Debette S, Wolf P A, Beiser A, Au R, Himali J J, Pikula A, Auerbach S, Decarli C, Seshadri S

Abstract excerpt

OBJECTIVES: Studies of autosomal dominant Alzheimer disease (AD) have shown structural and cognitive changes in mutation carriers decades prior to clinical disease. Whether such changes are detectable in offspring of persons with sporadic dementia remains unknown. We related prospectively verified parental dementia to brain MRI and cognitive testing in the offspring, within a 2-generational community-based...

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Identifiers

PMID: 20007524
DOI: 10.1212/WNL.0b013e3181c67833
PMCID: PMC2790222

Genes

APOE

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Source receipt: pubmed, retrieved 7 Sept 2026.

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