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Article

Genetic insights into the relationship between age at menarche and mental health-related phenotypes.

European psychiatry : the journal of the Association of European Psychiatrists - 11 May 2026

Chen Yang, Li Zhi, Huang Siwei, Li Xinrui, Jiao Wen, Gu Wangyang, Xue Peng, Mei Hao, Liu Shijian

Abstract excerpt

BACKGROUND: Multiple observational studies have reported associations between age at menarche (AAM) and mental health problems, yet their shared genetic architecture remains poorly characterized. METHODS: We leveraged genome-wide association study summary statistics for AAM and 15 mental health-related phenotypes. We conducted a multi-method integrative analysis encompassing linkage disequilibrium score...

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Identifiers

PMID: 42108995
DOI: 10.1192/j.eurpsy.2026.12214
PMCID: PMC13227137

Genes

LIN28B

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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