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Joint-Tissue Integrative Analysis Identified Hundreds of Schizophrenia Risk Genes.

Molecular neurobiology - 1 Jan 2022

Wu Yong, Yu Xiao-Lin, Xiao Xiao, Li Ming, Li Yi

Abstract excerpt

Genome-wide association studies (GWAS) have identified a large number of schizophrenia risk variants, and most of them are mapped to noncoding regions. By leveraging multiple joint-tissue gene expression data and GWAS data, we herein performed a transcriptome-wide association study (TWAS) and Mendelian randomization (MR) analysis and identified 144 genes whose mRNA levels were related to genetic risk of...

Topics

Dorsolateral Prefrontal Cortex
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Polymorphism, Single Nucleotide
Schizophrenia
Transcriptome

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34628600
DOI: 10.1007/s12035-021-02572-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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