Article
Joint-Tissue Integrative Analysis Identified Hundreds of Schizophrenia Risk Genes.
Molecular neurobiology - 1 Jan 2022
Wu Yong, Yu Xiao-Lin, Xiao Xiao, Li Ming, Li Yi
Abstract excerpt
Genome-wide association studies (GWAS) have identified a large number of schizophrenia risk variants, and most of them are mapped to noncoding regions. By leveraging multiple joint-tissue gene expression data and GWAS data, we herein performed a transcriptome-wide association study (TWAS) and Mendelian randomization (MR) analysis and identified 144 genes whose mRNA levels were related to genetic risk of...
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