Single-cell eQTL and Mendelian randomization analyses of shared genetic architecture in major depressive disorder and schizophrenia.

Abstract excerpt

Schizophrenia (SCZ) and major depressive disorder (MDD) are severe psychiatric disorders with substantial shared genetic liability and frequent clinical co-occurrence, yet their shared cell type-specific genetic mechanisms remain unclear. We integrated single-cell expression quantitative trait locus (sc-eQTL) data from eight major brain cell types with large-scale genome-wide association study (GWAS) summary...

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• Genome-Wide Association Study
• Major Depressive Disorder
• Mendelian Randomization Analysis
• Oligodendroglia
• Quantitative Trait Loci