Article
Local production of tenascin-C acts as a trigger for monocyte/macrophage recruitment that provokes cardiac dysfunction.
Cardiovascular research - 1 Jan 2018
Abbadi Dounia, Laroumanie Fanny, Bizou Mathilde, Pozzo Joffrey, Daviaud Danièle, Delage Christine, Calise Denis, Gaits-Iacovoni Fréderique, Dutaur Marianne, Tortosa Florence, Renaud-Gabardos Edith, Douin-Echinard Victorine, Prats Anne-Catherine, Roncalli Jerome, Parini Angelo, Pizzinat Nathalie
Abstract excerpt
Aims: Tenascin-C (TNC) is an endogenous danger signal molecule strongly associated with inflammatory diseases and with poor outcome in patients with cardiomyopathies. Its function within pathological cardiac tissue during pressure overload remains poorly understood. Methods and results: We showed that TNC accumulates after 1 week of transverse aortic constriction (TAC) in the heart of 12-week-old male mice. By...
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