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Article

Mechanical signaling through the discoidin domain receptor 1 plays a central role in tissue fibrosis

7 Mar 2018

Abstract excerpt

The preservation of tissue and organ architecture and function depends on tightly regulated interactions of cells with the extracellular matrix (ECM). These interactions are maintained in a dynamic equilibrium that balances intracellular, myosin-generated tension with extracellular resistance conferred by the mechanical properties of the extracellular matrix. Disturbances of this equilibrium can lead to the...

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Identifiers

PMID: 29513135
DOI: 10.1080/19336918.2018.1448353

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