Article
C1q/Tumor Necrosis Factor-Related Protein-9 Regulates the Fate of Implanted Mesenchymal Stem Cells and Mobilizes Their Protective Effects Against Ischemic Heart Injury via Multiple Novel Signaling Pathways.
Circulation - 28 Nov 2017
Yan Wenjun, Guo Yongzhen, Tao Ling, Lau Wayne Bond, Gan Lu, Yan Zheyi, Guo Rui, Gao Erhe, Wong G William, Koch Walter L, Wang Yajing, Ma Xin-Liang
Abstract excerpt
BACKGROUND: Cell therapy remains the most promising approach against ischemic heart injury. However, the poor survival of engrafted stem cells in the ischemic environment limits their therapeutic efficacy for cardiac repair after myocardial infarction. CTRP9 (C1q/tumor necrosis factor-related protein-9) is a novel prosurvival cardiokine with significantly downregulated expression after myocardial infarction. Here...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.