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Article

Diabetes Induces Cardiac Fibroblast Activation, Promoting a Matrix-Preserving Nonmyofibroblast Phenotype, Without Stimulating Pericyte to Fibroblast Conversion.

Journal of the American Heart Association - 21 Mar 2023

Alex Linda, Tuleta Izabela, Hanna Anis, Frangogiannis Nikolaos G

Abstract excerpt

Background Interstitial and perivascular fibrosis may contribute to diabetes-associated heart failure. Pericytes can convert to fibroblasts under conditions of stress and have been implicated in the pathogenesis of fibrotic diseases. We hypothesized that in diabetic hearts, pericytes may convert to fibroblasts, contributing to fibrosis and to the development of diastolic dysfunction. Methods and Results Using...

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Identifiers

PMID: 36892073
DOI: 10.1161/JAHA.122.027463
PMCID: PMC10111546

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