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Article

Hematopoietic Id Deletion Triggers Endomyocardial Fibrotic and Vascular Defects in the Adult Heart.

Scientific reports - 8 Jun 2017

Chang Corey, Zhao Qingshi, Gonzalez J Patrick, Kim Jung H, Alzahrani Kamal, Del Re Dominic, Fraidenraich Diego

Abstract excerpt

Inhibitor of DNA binding (Id) proteins play important roles in regulating cardiac development via paracrine signaling. Id1/Id3 knockout mice die at mid-gestation with multiple cardiac defects. Single Id knockout studies have not reported cardiomyopathies. To bypass embryonic lethality we used Tie2CRE-mediated recombination to conditionally delete Id1 against global Id3 ablation (Id cDKOs), which develops...

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Identifiers

PMID: 28596553
DOI: 10.1038/s41598-017-03160-7
PMCID: PMC5465087

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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