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Article

Structural basis and functional mining of active site loop for fine tuning substrate affinity of L-asparaginase from Bacillus licheniformis.

Journal of hazardous materials - 1 Jul 2026

Chi Huibing, Jiang Qingwei, Wang Weiwu, Niu Jiafeng, Zhang Guizheng, Xu Dongqing, Lu Zhaoxin, Zhu Ping, Lu Fengxia, Ran Tingting

Abstract excerpt

The widespread presence of the environmental contaminant acrylamide (AA) in thermally processed foods has been linked to serious environmental and health challenges. Although the formation of AA can be fundamentally inhibited by L-asparaginase (L-ASNase), its removal efficiency is highly dependent on substrate affinity. However, the structural mechanism by which the affinity of this L-ASNase is regulated remains...

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Identifiers

PMID: 42102559
DOI: 10.1016/j.jhazmat.2026.142189

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ASL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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