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Engineering Tk1656, a highly active l-asparaginase from Thermococcus kodakarensis, for enhanced activity and stability.

International journal of biological macromolecules - 1 Nov 2024

Sania Ayesha, Muhammad Majida Atta, Sajed Muhammad, Ahmad Nasir, Aslam Mehwish, Tang Xiao-Feng, Rashid Naeem

Abstract excerpt

l-Asparaginases catalyze the hydrolysis of l-asparagine to l-aspartic acid and ammonia. These enzymes have potential applications in therapeutics and food industry. Tk1656, a highly active and thermostable l-asparaginase from Thermococcus kodakarensis, has been proved effective in selective killing of acute lymphocytic leukemia cells and in reducing acrylamide formation in baked and fried foods. However, it...

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PMID: 39389482
DOI: 10.1016/j.ijbiomac.2024.136442

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