Article
Elucidation of the Reaction Mechanism of Cavia porcellus l-Asparaginase: A QM/MM Study.
Journal of chemical information and modeling - 9 Jan 2023
Sánchez Leslie, Medina Fabiola E, Mendoza Fernanda, Febres-Molina Camilo, Jaña Gonzalo A
Abstract excerpt
The l-asparaginase (l-ASNase) enzyme catalyzes the conversion of the non-essential amino acid l-asparagine into l-aspartic acid and ammonia. Importantly, the l-ASNases are used as a key part of the treatment of acute lymphoblastic leukemia (ALL); however, despite their benefits, they trigger severe side effects because they have their origin in bacterial species (Escherichia coli and Erwinia chrysanthemi)....
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