Biochemical insights into the key residue substituents of an L-asparaginase from Thermococcus kodakarensis and their application in acrylamide mitigation.

Abstract excerpt

L-Asparaginases are enzymes of biotechnological importance due to their applications in anticancer therapy and acrylamide mitigation. Identification of key residues is crucial for developing improved variants. A conserved triad, Asp Ser Thr, is found in the characterized thermophilic L-asparaginases. In order to evaluate structure-function relationships, this conserved triad in the L-asparaginase of Thermococcus...

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