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Enhanced Thermostability and Molecular Insights for l -Asparaginase from Bacillus licheniformis via Structure- and Computation-Based Rational Design

7 Nov 2022

Abstract excerpt

l -Asparaginase has gained much attention for effectively treating acute lymphoblastic leukemia (ALL) and mitigating carcinogenic acrylamide in fried foods. Due to high-dose dependence for clinical treatment and low mitigation efficiency for thermal food processes caused by poor thermal stability, a method to achieve thermostable l -asparaginase has become a critical bottleneck. In this study, a rational design...

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PMID: 36341695
DOI: 10.1021/acs.jafc.2c05712

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