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Integrative genomic analysis of pediatric T-cell lymphoblastic lymphoma reveals candidates of clinical significance

5 Nov 2020

Abstract excerpt

T-cell lymphoblastic lymphoma (T-LBL) is a heterogeneous malignancy of lymphoblasts committed to T-cell lineage. The dismal outcomes (15%-30%) after T-LBL relapse warrant establishing risk-based treatment. To our knowledge, this study presents the first comprehensive, systematic, integrated, genome-wide analysis including relapsed cases that identifies molecular markers of prognostic relevance for T-LBL. NOTCH1...

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PMID: 33152759
DOI: 10.1182/blood.2020005381

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