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Article

Whole exome sequencing reveals rare DNA repair gene variants in BRCA1/2-negative Arab early-onset breast cancer patients.

Scientific reports - 7 May 2026

Bu Rong, Siraj Abdul K, Abdul Razzaq Eman A, Iqbal Kaleem, Parvathareddy Sandeep Kumar, Azam Saud, Qadri Zeeshan, Thangavel Saravanan, Haqawi Wael, Al-Kuraya Khawla S

Abstract excerpt

Early-onset Breast Cancer (EOBC), defined as breast cancer diagnosed at or before the age of 40 years, represents a small but clinically aggressive subset of breast cancer cases. While pathogenic variants in BRCA1/2 might explain some of this risk, many EOBC cases remain unexplained. This study aimed to investigate rare germline variants in DNA repair genes that may contribute to EOBC among BRCA1/2-negative...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42098349
DOI: 10.1038/s41598-026-50634-8
PMCID: PMC13350974

Genes

BRCA1
CLK2
DNA2
EME2
RAD51B
SWI5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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