Article

Multi-omics analysis in suspected hereditary breast and ovarian cancer cases reveals novel candidate susceptibility factors

2026-05-20

Abstract excerpt

<title>Abstract</title> <p> More than 80% of patients who meet clinical criteria for hereditary breast and ovarian cancer (HBOC) do not show pathogenic variants in <italic>BRCA1, BRCA2</italic> and other diagnostically consented core genes <italic>.</italic> We hypothesized that variants in further DNA repair genes, cryptic genomic alterations or polygenic factors may explain HBOC risk. We studied 134 patien...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 080326c5-fe1d-56f0-bd49-b8a1c890e5fb
DOI: 10.21203/rs.3.rs-9632891/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Multi-omics analysis in suspected hereditary breast and ovarian cancer cases reveals novel candidate susceptibility factorsDOI 10.21203/rs.3.rs-9632891/v1Read

Whole genome profiling of 400 patients at risk for hereditary cancer in a Brazilian cohortSemantic proximity Read

Hereditary Breast and Ovarian Cancer: An Updated Primer for OB/GYNs.Semantic proximity Read

Identification of novel exonic variants responsible for hereditary breast and ovarian cancer in West Indian populationSemantic proximity Read

Reanalysis of BRCA1/2 negative high risk ovarian cancer patients reveals novel germline risk loci and insights into missing heritability.Semantic proximity Read

Molecular Features and Clinical Management of Hereditary Gynecological Cancers.Semantic proximity Read

Hereditary breast and ovarian cancer: new genes in confined pathways.Semantic proximity Read

Molecular Characterization of Hereditary Breast and Ovarian Cancer Patients from a Public Precision Medicine Service in the Southeast Brazilian PopulationSemantic proximity Read

Whole exome sequencing reveals a combination of rare high and low penetrance variants that correlates with familial breast cancer relative riskSemantic proximity Read

Whole-Exome Sequencing Identifies Novel Germline Risk Variants for Breast Cancer in Ghanaian WomenSemantic proximity Read

Association of Breast and Ovarian Cancers With Predisposition Genes Identified by Large-Scale Sequencing.Semantic proximity Read

Hereditary breast and ovarian cancer (HBOC): review of its molecular characteristics, screening, treatment, and prognosis.Semantic proximity Read

Variants of uncertain significance in the era of high-throughput genome sequencing: a lesson from breast and ovary cancers.Semantic proximity Read