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Pathogenicity Reclassification of Genetic Variants Related to Early-Onset Breast Cancer among Buryat Women

2021-09-01

Abstract excerpt

<h4>Background: </h4> Germline alterations in ATM, BRCA1, BRCA2, and other genes are responsible for early-onset breast cancer. However, up to 20% of molecular tests report genetic variant of unknown significance (VUS) or novel variants that have never been previously described and their clinical significance are unknown. An existing open access databases (ClinVar, BIC, and ENIGMA and other) play an important role...

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Literature Corpus work
0f636c00-faab-5eff-a63e-b85bc740c414
DOI
10.21203/rs.3.rs-783155/v1
Open publication

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Pathogenicity Reclassification of Genetic Variants Related to Early-Onset Breast Cancer among Buryat WomenDOI 10.21203/rs.3.rs-783155/v1
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