Article

Whole-Exome Sequencing Identifies Novel Germline Risk Variants for Breast Cancer in Ghanaian Women

2026-06-16

Abstract excerpt

<title>Abstract</title> <p> This study explored germline risk variants in a Ghanaian breast cancer cohort (BCOPGh-Ghana Breast Cancer Omics Project). Whole-exome sequencing of 113 unrelated breast cancer cases, analysed alongside 43 controls, revealed 26 pathogenic variants in 27.4% (31/113) of the cases. Variants in DNA-damage-response genes, including 3 canonical breast cancer susceptibility genes, were found...

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Literature Corpus work: bc507e83-bb99-5f8c-b67d-7f59811096ed
DOI: 10.21203/rs.3.rs-9972157/v1

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