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Article

Exome-Wide Association Analysis Identifies Rare Germline Susceptibility Variants in Early-Onset Breast Cancer Among Saudi Women.

International journal of molecular sciences - 11 Feb 2026

Bu Rong, Iqbal Kaleem, Parvathareddy Sandeep Kumar, Azam Saud, Qadri Zeeshan, Abdul Razzaq Eman A, Al-Dayel Fouad, Siraj Abdul K, Al-Kuraya Khawla S

Abstract excerpt

Early-onset breast cancer (EOBC) is disproportionately common in Saudi Arabia, where women present nearly a decade earlier than in Western countries, suggesting unique inherited susceptibility. While BRCA1/2 explain part of the hereditary risk, the contribution of rare coding variants in Arab EOBC remains unclear. Whole-exome sequencing was performed on germline DNA from 102 unrelated Saudi EOBC patients and 1395...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41751868
DOI: 10.3390/ijms27041732
PMCID: PMC12940663

Genes

BRCA1
TP53
FRMPD3
GUCY2F
NOTCH4
OR12D3
SHROOM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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