Extensive antagonistic variants across the human genome.

Abstract excerpt

Pleiotropic conflict, where a genetic locus has antagonistic effects on different traits, is a common phenomenon observed in animals and plants. While pleiotropy has been widely reported in humans, there is no systematic study of pleiotropic conflict in humans. Here, we leverage summary statistics from genome-wide association studies of complex diseases and traits derived from large-scale population cohorts to...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gene Frequency
• Share to Genetic Pleiotropy
• Share to Genetic Variation