Article

Extensive antagonistic variants across human genome

2024-11-29

Abstract excerpt

Pleiotropic conflict, where a genetic locus has antagonistic effects on different traits, is a common phenomenon observed in animals and plants. While pleiotropy has been widely reported in humans, there is no systematic study of pleiotropic conflict in humans. Here, we leverage GWAS summary statistics of complex diseases and traits derived from large-scale population cohorts to identify pleiotropic regions with c...

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Literature Corpus work: 4c0fc95b-9778-5041-a2b1-ed6796d50bfd
DOI: 10.1101/2024.11.28.24318135

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